Objective
"Sudden cardiac death (SCD) following ventricular fibrillation (VF) is a major cause of mortality in the industrialised world. VF is characterised by chaotic electrical activity in the ventricles leading to severe cardiac dysfunction. Thus far, the underlying mechanisms for the initiation and maintenance of VF are not fully understood. Recent clinical developments in the treatment of VF by the Host’s laboratory have discovered distinct electrical activity associated with a specialised cell-type, Purkinje fibres, which were found to precede the spontaneous beats that manifest VF. Targeted radiofrequency (RF) ablation of these sources has markedly improved treatment and the rates of recurrence of arrhythmias in patients suffering from idiopathic VF. There is also growing evidence that the Purkinje system may be involved in arrhythmogenesis in cardiac pathologies such as myocardial infarction. Therefore, this proposal aims to utilise in vivo electrophysiological techniques in combination with a newly developed ex vivo optical imaging technique on a large animal model (sheep) to determine the roles of Purkinje fibres in the development of life-threatening arrhythmias with a focus on improving the effectiveness of ablation therapies. Furthermore, this approach shall be applied to further investigate a cardiac disease model that is at significant risk of arrhythmogenesis, myocardial infarction. The proposed aims shall be carried out in vivo using MRI and epicardial and endocardial electrophysiological recordings. This will be followed by optical mapping of ex vivo coronary-perfused ventricular preparations providing insight into the 3D organisation of electrical activity. These techniques will provide the appropriate tools for determining the precise location of arrhythmogenic sources, the organisation of arrhythmias and the roles of Purkinje fibres. Successful completion of these research goals will have an important impact on future therapies for sudden cardiac death."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology electrical engineering, electronic engineering, information engineering information engineering telecommunications radio technology radio frequency
- medical and health sciences clinical medicine cardiology cardiovascular diseases cardiac arrhythmia
- social sciences sociology demography mortality
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
33000 Bordeaux
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.