Objective
"Dendritic cells (DC) are the front-line of virus detection and trigger the response of the innate and adaptive immune system. DCs ""patrol"" in the body and seek pathogens such as viruses. When they catch viruses, they initiate immune responses primarily in lymph nodes and lymphoid tissue. DCs acquire a mature phenotype while they migrate towards the lymphoid tissues in order to process and present the antigens derived from viruses. They also produce various cytokines and chemokines, substances with pro-inflammatory properties. Antigen presentation by DCs can activate the immune system by inducing specific CD4 and CD8 T lymphocytes responses, responsible for destroying the virus. DCs are relatively resistant to infection by HIV. A cell antiviral factor named SAMHD1, was recently identified as protecting DCs and macrophages from productive infection by HIV-1. We want to characterize the SAMHD1 mechanism of action, how and why it protects DCs from HIV infection. HIV infection is mainly achieved by the formation of cellular contact between infected cells and target cells, thus we aim to examine the role of SAMHD1 during these contacts. We will also study the role of SAMHD1 in the induction of the immune response against HIV. This project is in collaboration with the team of Monsef Benkirane, which has recently identified the protein SamHD1, and the team of Yves Levy. We expect to unmask how HIV has evolved to escape from the immune response; a relevant issue to better understand why nowadays treatments have failed to completely eradicate the virus."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.