Objective
"Two-dimensional (2D) nuclear magnetic resonance is a diagnostic technique that has revolutionized structural biology. A wealth of spectroscopic information can be obtained by extrapolating 2D techniques to the optical frequency domain, using ultrashort light pulses. 2D electronic spectroscopy (2DES) allows fundamentally new insights into the structure and dynamics of multi-chromophore systems, by measuring how the electronic states of chromophores interact with one another and transfer electronic excitations. Due to technical difficulties, 2DES has been limited so far to the visible range, while most biomolecules absorb in the ultraviolet (UV). This project aims at extending 2DES to the challenging and still uncharted UV-domain and applying it to the study of the photophysics of genomic systems and of the secondary structure of proteins.
Nature has engineered DNA molecules to be photostable, so that harmful photochemical processes are minimized. 2DES will unravel the molecular mechanisms of the photoinduced electronic intra/inter-chromophore events in DNA, exposing the energy dissipation pathways which are responsible for its photoprotection.
2DES will be also established as a new diagnostic tool for structural studies of polypeptides and proteins, relying on the UV absorbing peptide bonds and aromatic residues, the latter acting as native local structural probes. 2DES will provide sensitive information on the misfolding/aggregation processes responsible for a wide class of diseases, with the speed of standard optical techniques but with a much greater information content. This will bridge the experimental gap between crude estimates of protein unfolding and full structure determination, enabling rapid assessment of which variants are worth of deeper structural studies.
To realize the full power of 2DES, experiments will be combined with simulations and electronic calculations that are necessary to correlate the data with molecular states and structures."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences molecular biology structural biology
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-ADG_20110209
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
20133 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.