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Elucidating the relationship between heterozygosity and fitness in a natural marine mammal population

Obiettivo

Many important fitness traits including longevity, reproductive success, parasite resistance, territory-holding ability, song complexity and even attractiveness often correlate with heterozygosity in natural populations. Where documented, such heterozygosity-fitness correlations (HFCs) have the clear potential to influence interactions between pathogens and their hosts and the evolution of mate choice. However, because most studies use only around ten neutral microsatellite markers, the proximate mechanisms underlying HFCs remain obscure. Fortunately, next-generation sequencing approaches now make it possible to sequence DNA cheaply and on a massive scale, allowing large panels of Single Nucelotide Polymorphisms (SNPs) to be developed in virtually any organism. By screening these in the Antarctic fur seal, a model system in which unusually high-quality measures of fitness are available, I will for the first time determine the mechanisms underlying a range of HFCs in a natural population and uncover actual genes linked to variation in key traits including longevity, reproductive success and attractiveness.

Invito a presentare proposte

FP7-PEOPLE-2011-CIG
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Coordinatore

UNIVERSITAET BIELEFELD
Contributo UE
€ 100 000,00
Indirizzo
UNIVERSITAETSSTRASSE 25
33615 Bielefeld
Germania

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Regione
Nordrhein-Westfalen Detmold Bielefeld, Kreisfreie Stadt
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Erika Sahrhage (Ms.)
Collegamenti
Costo totale
Nessun dato