Objetivo The current research proposes new optical spectroscopic and interferometric microscopy and nanoscopy techniques for accurate measurements and visualization of biological cell structure, organization, stiffness and dynamics by recording the cell spatial, temporal, and refractive-index structure on sub-wavelength and sub-Hertz scales. The following objectives are proposed:(a) Novel optical-mechanical signatures of cancer cells measured by wide-field digital interferometry: I propose to establish multi-disciplinary cancer biomarker using the stiffness signatures of cancer cells measured in a noncontact, quantitative and label-free manner by wide-field digital interferometry (WFDI).(b) Interferometric and spectroscopic diagnosis of red blood cell diseases: I propose to measure mechanical and morphological properties of live red blood cells (RBCs) with extremely high sensitivity in a non-destructive, noncontact and label-free manner, as a mean to learn about the biomechanical properties of the RBC membrane and as a novel diagnosis tool for diseases that change morphology and mechanical properties of RBCs.(c) Developing plasmonic-nanoparticle-based interferometric methods for Alzheimer's disease research: I propose to develop new nano-sensing and imaging modalities as a means to monitor degradation of neuronal function due to Alzheimer's disease. I will use photothermal optical coherence tomography with nanoparticles bound to amyloid beta to detect the degeneration in neuronal activity. This system will be combined with a low-coherence WFDI system for quantitative phase imaging of rapid dynamic neuronal phenomena.The proposed objectives are highly interdisciplinary, involving optical engineering, sensing in biological systems, biophysics, nanoscience, neurobiology, and disease research, and have a great potential of providing new means for diagnosis and monitoring of diseases in the sub-cellular level, as well as aiding in identifying new avenues for therapy. Ámbito científico natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesbiophysics Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Convocatoria de propuestas FP7-PEOPLE-2011-CIG Consulte otros proyectos de esta convocatoria Régimen de financiación MC-CIG - Support for training and career development of researcher (CIG) Coordinador TEL AVIV UNIVERSITY Aportación de la UE € 100 000,00 Dirección RAMAT AVIV 69978 Tel Aviv Israel Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Lea Pais (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos