Objective
"The overarching aim of the project is to establish a cause-effect relationship among the mitochondrial processes related to ageing in fish (mitochondrial membrane composition, lipid metabolism, ROS production, antioxidant activities, mitochondrial DNA expression), which will advance our understanding of these mechanisms in ectotherms in order to develop a vertebrate model of ageing. The project will require a multi-disciplinary approach utilising molecular biology and biochemistry. Techniques include subcellular fractionation to obtain the mitochondrial fraction, lipid analyses including thin-layer chromatography (TLC) and gas-chromatography (GC) for phospholipid and fatty acid analysis, biochemical assays to assess peroxidation processes, and molecular analyses including PCR cloning of mitochondrial electron transport chain (ETC) cDNAs and gene expression studies to determine tissue distribution and effects of aging using quantitative real-time PCR.
The host institution will be the Institute of Aquaculture (IoA) at University of Stirling (Scotland, United Kingdom), a dedicated research Institute with an International reputation in research and post-graduate teaching. The work in the proposed project falls within the remit of the Molecular Nutrition Group at the IoA, a world-leading group in fish lipid and fatty acid metabolism, nutrition and molecular biology.
The proposed research project fits very well within the objectives of FP7 of the European Community. The project is part of research efforts that impact on human health through addressing the important issue of the establishment of a vertebrate model of ageing, which would shorten the phylogenetic distance respecting model and the human species. However, the project is also highly relevant to Theme 2 (Food, Agriculture and Fisheries, Biotechnology). This project will help us to consider new aspects in the fish farming and to improve the efficiency of Aquaculture activities and fish welfare."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
FK9 4LA Stirling
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.