Objective
Throughout the last thirty years, research on Rab GTPase proteins has brought light to their pivotal role in the regulation of several steps of intracellular trafficking. However, recent findings indicate that Rab proteins not only regulate individual transport steps, but they also function in a coordinated fashion in Rab GTPase cascades. Such cascades appear to be crucial for orchestrating sequential steps along transport pathways and for ensuring continuity in membrane traffic. Rab cascades have been found in the endocytic pathway of mammalian cells (Rab5/Rab7) as well as in the secretory pathway of yeast (Ypt32p/Sec4p) but none have been, so far, identified in the secretory pathways of the former. Therefore, the main goal of this research project is to identify Rab GTPase cascades in the post-Golgi trafficking of mammalian cells. By using a multidisciplinary approach, we propose to: 1) establish a comprehensive list of Rab GTPases involved in the post-Golgi trafficking from the trans-Golgi network to the plasma membrane and to the endolysosomal compartments; 2) determine the temporal recruitment of Rab GTPases to the post-Golgi vesicles associated with each one of the pathways and identify Rab cascades; 3) identify the Guanine nucleotide Exchange Factor (GEF) proteins involved in the cascades previously found. Achieving this work plan will increase our knowledge on the regulation of sequential trafficking steps, essential for the full understanding of human pathologies, like cancer and neurological diseases. Therefore, we will be contributing to the scientific European excellence by reaching one of the main goals of the Seventh Framework Programme regarding Health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- natural sciences biological sciences genetics nucleotides
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.