Cel "Attempts to prepare conjugate vaccines based on native capsular polysaccharide structures against Cryptococcus neoformans, a fungi increasingly recognized as a major health issue, has been ineffective due to the heterogeneity of the native material. In this project well defined synthetic oligosaccharide structures will be used instead. A library of structures corresponding to native structures will be synthesized and utilized in the production of glycomicroarrays. These will be employed to screen monoclonal antibodies raised against the native polysaccharide to determine their specificity and to identify protective carbohydrate epitopes. Recognized hits will be conjugated to carrier proteins using various spacers and conjugation techniques to produce a selection of vaccine candidates which efficiency will be evaluated in immunizing experiments in mice by collaborators. The training will be multidisciplinary covering complex oligosaccharide synthesis, conjugation techniques, microarray construction, protein and antibody purification and labelling, macromolecular characterisation and biological screening methods. The project is an international collaboration between chemists, immunologists and vaccine industry." Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2011-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Wkład UE € 191 938,20 Adres BELFIELD 4 Dublin Irlandia Zobacz na mapie Region Ireland Eastern and Midland Dublin Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Donal Doolan (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
