Objective
"Hepatitis B virus (HBV), an hepatotropic non-cytopathic DNA virus, still represents a global health problem, with million of deaths for year because of complication of chronic infection. Chronic infection and its outcome are believed a consequence of defective antiviral response, mainly in T-cell arm, probably mediated by prolonged exposition to large amounts of viral antigens. Recently, many advancements have been done on virus-specific CD8 dysfunction or “exhaustion”, while far less is known about the role of other components of immune response. Thus, aims of the present proposal are the evaluation of phenotype and function of CD4 T cells and B cells in both acute self-limited HBV infection, and in chronic HBV, in order to identify correlates of protection, and additional markers of immune impairment. The project will focus on multiple immunological parameters: dynamics of CD4 memory development, and lineage differentiation, B cells memory development and antibodies functional assays, in acute self limited infection; degree and role, if any, of CD4 T and B cells exhaustion in chronic infection, with different degree of viral control. The analysis will be conducted on cryopreserved PBMCs samples of patients affected by HBV (acute or chronic) and will be performed by both molecular and cellular approaches. Interestingly, many of them have been developed at the host institution. Thus, in addition to the possibility to develop a challenging project of strong impact, due to training that the host will provide, the permanence at the host institution, where multiple competences of very high scientific level coexist, will represent for the applicant an unique experience for scientific and working career."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences infectious diseases DNA viruses hepatitis B
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6500 Bellinzona
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.