POWORMADProject reference: 303074
Funded under :
A Powerful Enantioselective Organocatalytic Approach to the Total Synthesis of Madangamine Alkaloids
Total cost:EUR 200 371,8
EU contribution:EUR 200 371,8
Coordinated in:United Kingdom
Topic(s):FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"
Call for proposal:FP7-PEOPLE-2011-IEFSee other projects for this call
Funding scheme:MC-IEF - Intra-European Fellowships (IEF)
"The projet concerns the development of a powerful first total synthesis of the Madagamine alkaloids. The route starts with an organocatalytic enantioselective and diastereoselective Michael addition of cyanoacetate pronucleophiles to a nitrocyclohexene derivative, as a key step to the formation of the ABC core. When the product of this reaction is subjected to a nitro-Mannich, Mannich reaction cascade this should allow us to construct the core of the madangamine alkaloids rapidly, selectively and on scale. The overall synthetic strategy has two parts. The first concerns a fast and enantioselective assembly of diazatricyclic core common to all madangamines (ABC rings). The second concerns easy and efficient ways to build the two macrocyclic rings (D and E rings), which play a fundamental role in their biological activity. The project combines, catalysis, total synthesis, structure elucidation and evaluation of biological properties."
EU contribution: EUR 200 371,8
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