Objective
Nanostructured functional materials are undoubtedly one of the main focal points in academic and industrial research communities. Nature’s own ‘bottom-up’ strategy for the construction of immensely complex and sophisticated nanoscaled systems have served as an inspiration for ground-breaking developments in the field of supramolecular chemistry. I aim to combine self-assembly and self-organization for the fabrication of complex supramolecular systems with specific functionality. I propose to use peptide discotics for the controlled self-assembly of supramolecular functional nanoparticles in water and target molecular imaging studies in order to develop Supramolecular Biomedical Materials.
I will establish a set of semi-empirical rules, a packing parameter, for the design of supramolecular colloidal particles. The strategy of frustrated growth will aim to balance out positive non-covalent interactions with repulsive forces. Thereby the growth, stability and biocompatible surface functionalisation of the architectures can be controlled, aiming at sizes below 20 nm. The resulting supramolecular materials will be applied in molecular imaging, the development of nanoparticulate targeted and multimodal contrast agents.
The elegance and uniqueness of these Supramolecular Biomedical Materials is that following the initial targeting event, the self-assembled scaffolds will disassemble into their small building blocks. This optimises secretion by the renal system and at the same time, the highly ‘effective’ imaging is also retained because of the high local concentration of the imaging agent, thus enhancing overall contrast, sensitivity and resolution of for example cardiovascular disease processes. This will significantly reduce the residence times of the targeted agent, which is one of the major limitations in current biomedical applications using non-reversible nanoparticulate imaging.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
55122 MAINZ
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.