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Content archived on 2024-06-18

Synthesis of molecular probes for cancer research based on priviliged natural products through a novel enantioselective oxidative arylation technology

Objective

Enantioselective catalysis continues to be a necesarily expanding part of Organic Chemistry and Synthesis to be able to provide the enantiopure compounds that Society demands in a straightforward and sustainable way.
This research proposal is aimed at doing so through the development of new enantioselective oxidative arylation reactions a completely unprecedented research field. Moreover, the molecular structures and synthetic targets have been selected in close collaboration with the group of Dr. Murrell at CRUK Cambridge. This collaboration is aimed at understanding the processes of cancer generation and growth at the molecular level through development of small molecule histone methylation and acetylation modulators. To study such processes a priviliged and synthetically challenging familiy of natural products is targeted: the pyrroloindole alkaloids. Development of molecular probes inspired by these products and demonstration of the total synthesis of some members will be accomplished through the development of appropiate chemical tools. The synthesis of these compounds will enable multidisciplinar research to study the particularities of oncogenesis.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2011-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
EU contribution
€ 200 371,80
Address
TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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