Objective
Immune response is energetically demanding process and although an improper regulation of energetic metabolism during immune challenges leads to various complications in human patients it is largely unknown how is the energetic metabolism regulated during the immune response. Extracellular adenosine is a strong candidate for this type of regulation; nevertheless it has never been studied for such role. Our work using Drosophila as a model strongly supports the view of adenosine being the signal connecting energy reallocation with immune response. The regulation of extracellular-adenosine levels and its signaling are now well defined in flies and the model allows various manipulations with the adenosine system in vivo. Therefore the model is now perfectly suitable for a systematic analysis of the adenosine regulation of energetic metabolism during various infections which should lead to a better understanding of the energetic costs of mounting an immune response. Results of such analysis could greatly contribute to our knowledge of host-pathogen interactions and some highly important biomedical problems. Goal of this project is for the applicant to learn the complex methodology of Drosophila infections and use these obtained skills for the systematic analysis of the adenosine role during immune response.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
370 05 Ceske Budejovice
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.