Objective
"Gene transcription is a highly regulated process that allows cells to adapt during different stages of development and to changes in their environmental conditions. Specifically, RNA polymerase (Pol) III is responsible for the transcription of small, untranslated genes involved in fundamental cellular process such as mRNA processing (U6 snRNA) and translation (tRNAs). Recruitment of Pol III to its transcription start site requires the general transcription factor IIIB (TFIIIB), in mammals a known target of regulation by oncogenes and tumour suppressors. TFIIIB comprises three subunits, (TBP, Brf1 and Bdp1, Mr = 162 kDa) and, despite its crucial role in Pol III transcription initiation and its involvement in cancer cell proliferation, only limited structural information is available for this factor.
The project aims to reconstitute and to structurally describe the TFIIIB complex using biochemical and structural biology approaches and to characterize interactions between TFIIIB and Pol III using a combination of X-ray crystallography and single-particle electron microscopy. Description of the architecture of individual TFIIIB subunits, the entire TFIIIB complex, or a TFIIIB/Pol III complex, will contribute to improve our understanding of Pol III recruitment and Pol III transcription initiation. Furthermore, it will provide a structural framework to further elucidate the role of TFIIIB in Pol III misregulation and cancerogenesis."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.