Functional roles of long noncoding RNAs in drought stress responses of Arabidopsis

Projektinformationen

GreenLincs

ID Finanzhilfevereinbarung: 301466

Abgeschlossenes Projekt

Startdatum 1 August 2012

Enddatum 31 Juli 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 372 353,60

EU-Beitrag € 372 353,60

Koordiniert durch

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Ziel

In the coming decade declining water availability will exert increasing pressure on crop productivity worldwide. One of the solutions is to breed crop plants with enhanced drought tolerance. Whilst plant breeders are continuing to make progress in this direction, elucidation of the molecular basis of drought stress will help not only traditional breeding efforts but also formulate new transgenic strategies to produce plants with enhanced adaptability under conditions of water limitation.
The traditional view that protein coding genes are the only regulatory elements in the genome has been challenged by the discovery of miRNA genes and more recently by the discovery of transcription units producing long intergenic non-coding (linc)RNAs. Recent work in yeast and mammals indicate that these lincRNAs play important roles in cell differentiation, organ development and responses to stress. Still, very little is known about plant lincRNAs.
In this proposal we will use the model dicot plant, Arabidopsis, to investigate several novel molecular aspects of drought stress while providing the applicant advanced training in scientific and complementary skills to substantially enhance career development. We will first identify and characterize in detail lincRNAs whose expression levels are changed in response to drought. Preliminary results from Prof. Nam-Hai Chua’s lab (outgoing host) have uncovered more than a few hundred lincRNA genes that belong to this category and whose functions await discovery. This is a potential class of genes that may orchestrate drought responses by the epigenetic regulation of gene expression. Manipulation of the expression levels of these candidate lincRNAs will uncover their possible functions and analysis of chromatin modifications and neighboring gene expression will provide insights into their epigenomic mode of action under drought stress, potentially providing new candidate genes for genetic engineering in crop plants.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• agricultural sciences › agriculture, forestry, and fisheries › agriculture
• natural sciences › biological sciences › genetics › RNA
• natural sciences › biological sciences › zoology › mammalogy
• natural sciences › biological sciences › genetics › genomes

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2011-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2011-IOF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IOF - International Outgoing Fellowships (IOF)

Koordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Kontakt Verwaltung

Ludovic Hamon (Mr.)

• EU-Beitrag: € 372 353,60
• Adresse: RUE MICHEL ANGE 3 ; 75794 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten