InfOProject reference: 300686
Funded under :
Organoids as infection model
Total cost:EUR 183 805,8
EU contribution:EUR 183 805,8
Topic(s):FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"
Call for proposal:FP7-PEOPLE-2011-IEFSee other projects for this call
Funding scheme:MC-IEF - Intra-European Fellowships (IEF)
The mucosal surfaces of the human stomach and gut are in constant contact with bacteria and viruses. This encompasses the often mutually beneficial relationships with commensals as well as encounters with pathogens. The study of host-microbe interactions is hampered by a lack of suitable model systems: many bacteria or viruses cannot be cultured or existing models do not sufficiently recount the human disease. This project aims at the development of new in vitro models and the subsequent characterization of the host response to three microorganisms: the carcinogenic bacterium Helicobacter pylori, the most common cause for non-bacterial gastroenteritis, Norovirus, and the commensal Small Filamentous Bacteria. A culture system that was recently developed in lab of Dr. Clevers will be used in which adult stem cells give rise to three-dimensional structures (‘organoids’) resembling mature, polarized epithelium of the stomach, small intestine and colon.
EU contribution: EUR 183 805,8
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