Cel The mucosal surfaces of the human stomach and gut are in constant contact with bacteria and viruses. This encompasses the often mutually beneficial relationships with commensals as well as encounters with pathogens. The study of host-microbe interactions is hampered by a lack of suitable model systems: many bacteria or viruses cannot be cultured or existing models do not sufficiently recount the human disease. This project aims at the development of new in vitro models and the subsequent characterization of the host response to three microorganisms: the carcinogenic bacterium Helicobacter pylori, the most common cause for non-bacterial gastroenteritis, Norovirus, and the commensal Small Filamentous Bacteria. A culture system that was recently developed in lab of Dr. Clevers will be used in which adult stem cells give rise to three-dimensional structures (‘organoids’) resembling mature, polarized epithelium of the stomach, small intestine and colon. Dziedzina nauki natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesmedical biotechnologycells technologiesstem cells Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2011-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Wkład UE € 183 805,80 Adres KLOVENIERSBURGWAL 29 HET TRIPPENHUIS 1011 JV AMSTERDAM Niderlandy Zobacz na mapie Region West-Nederland Noord-Holland Groot-Amsterdam Rodzaj działalności Research Organisations Kontakt administracyjny Don Van Velzen Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych