Objective
The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded into the sarcomere. Thereby, titin and nebuliun with dual structural scaffold and biosensing functions intricately connect the sarcomere to muscle remodelling.
Molecular progress on titin- and nebulin based sarcomeric signalosomes has been accelerated during recent years, and the next step require is a functional understanding regarding how titin and nebulin and associated signaling complexes generate biochemical signals, and how these signals in turn, control muscle trophicity and remodelling. This network addresses this issue by bringing together teams leading in titin and nebulin muscle biology from America, Japan, and the US. Each team will contribute specific resources to study titin- and nebulin-based muscle remodelling, including transgenic animal models, compounds from high-throughput screens, and intricate myofibril mechanics. Importantly, SARCOSI will provide the European researchers resources that are otherwise not available.
While the participants have collaborated and published together occassionally in the past, the SARCOSI network will establish long-term strategic EU transcontinental partnerships by staff exhanges and joint mentoring of thesis and postdoctoral projects. The exchange of staff will enhance the transfer of technologies and models between participating laboratories. By working close together and sharing resources, progress will be achieved much faster than working separately in the clinically important field of pathological muscle remodelling that contributes to both chronic heart failure and to skeletal muscle sarcopenia
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine cardiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IRSES
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-IRSES - International research staff exchange scheme (IRSES)
Coordinator
69117 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.