Investigating how pathogen effector recognition by plant resistance proteins activates defence

Projektinformationen

Plant-Def-Mech

ID Finanzhilfevereinbarung: 299621

Abgeschlossenes Projekt

Startdatum 31 Mai 2012

Enddatum 30 Mai 2014

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 278 807,40

EU-Beitrag € 278 807,40

Koordiniert durch

THE SAINSBURY LABORATORY
United Kingdom

Ziel

Plants can perceive attacking pathogens via the recognition of conserved Pathogen Associated Molecular Patterns (PAMPs) resulting in activation of a multi-level plant defence. Pathogens have evolved mechanisms to attenuate PAMP-triggered immunity (PTI) via specialized “effector” proteins translocated to the host cell. Effectors can influence diverse host cell pathways in order to manipulate the cell metabolism for the benefit of the pathogen. However, plants have involved specific resistance (R) proteins for pathogen effector recognition, which initiates strong defence culminating in a localized hypersensitive cell death response (HR), restricting pathogen spread (Effector Triggered Immunity, or ETI). Although PTI and ETI result in similar responses, the links between PTI and ETI remain obscure. The study of R protein recognition and signaling requires a well-established model system. The Arabidopsis thaliana resistance genes RRS1 and RPS4, encode TIR-NB-LRR proteins which confer resistance to baterial pathogens carrying the effector genes popP2 and avrRps4 respectively.
The overall aim of this proposal is to enhance our understanding of defence activation during ETI, and possible overlaps with PTI, by understanding the mechanisms of R-effector recognition and how this signals various defence responses. The work is strategically relevant as it aims to underpin the delivery of sustainable immunity in important crop species.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › cell biology › cell metabolism
• agricultural sciences › agriculture, forestry, and fisheries › agriculture

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2011-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

THE SAINSBURY LABORATORY

Kontakt Verwaltung

Debbie Feather (Ms.)

• EU-Beitrag: € 278 807,40
• Adresse: Norwich Research Park, Colney Lane ; NR47UH Norwich ; Vereinigtes Königreich
• Region: East of England › East Anglia › Norwich and East Norfolk
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten