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Content archived on 2024-06-18

Integration of Analyses among fMRI, Biophysical Models and Genetic Data

Objective

This project is interdisciplinary in character with three background topics. (1) Functional magnetic resonance imaging (fMRI), which has become an important technique in the study of the cognitive functions of the brain. This topic also has important applications in the routine diagnosis and prognosis of thoracic surgery and mental diseases. (2) Bioinformatics, which has developed into a key approach in the life sciences, relating molecular data to a number of genetic diseases. (3) Biophysical mathematical models, such as the leaky integrate-and-fire neuron, the Hodgkin-Hulexy model, neural mass models and the neural field equation. These have been utilized to study neuronal activities and functions at the cell and tissue level for many years.

The project will combine the three background topics, and is aimed towards the integration of data and models. It will establish a framework composed of modelling, mathematical analysis and statistical inference. The ultimate aim is the integration of fMRI, biophysical models and genetic data.

This will involve modelling and mathematical analysis to understand the underlying mechanisms due to the intrinsic complexity and noise of biological systems. The specific problems we intend to solve are: (1) Integration of EEG-fMRI data and a neuronal network model; (2) Integration of fMRI and genetic data; (3) An fMRI data analysis, towards diagnosing mental disorders; (4) Modelling and mathematic analysis.

The main goal of the project is to gain new insights into some mental disorders and, on the way, develop mathematical models and theory that can explain the observed phenomena. The significance of our findings for social and economic impacts should be considerable since the project will address fundamental issues related to the daily life of human beings. It will take advantage of the quantity and quality of data that are now available and the power of modern computers and mathematical techniques.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2011-IIF
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

UNIVERSITY OF WARWICK
EU contribution
€ 278 807,40
Address
KIRBY CORNER ROAD UNIVERSITY HOUSE
CV4 8UW COVENTRY
United Kingdom

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Region
West Midlands (England) West Midlands Coventry
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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