Objective
"Living cells have evolved a complex network of signaling pathways and adaptative responses which enable them to survive and adapt to diverse environmental challenges. Our increasing understanding of the molecular mechanism of cell signaling has revealed that reactive oxygen species (ROS) and reactive nitrogen species (RNS) act as signaling molecules to transfer extracellular or intracellular information and elicit specific responses. ROS/RNS mainly act through a set of reversible post-translational modifications (PTMs) of thiol residues on proteins among which nitrosylation and glutathionylation have emerged as key elements playing a major role in numerous fundamental cell processes and are implicated in a broad spectrum of human diseases. Emerging evidence suggests the existence of an intricate network of redox signaling pathways with a complex crosstalk between the different types of redox modifications. A specific pattern of redox-based protein modifications likely constitutes a molecular language that allows to trigger specific responses in response to the input signal. The aim of this project is to investigate, using an innovative proteomic technology, the temporal and qualitative dynamics of redox-based PTMs in vivo. The method will allow qualitative and time-resolved detection of nitrosylation and glutathionylation that will be analyzed simultaneously and specifically from each sample. This technology will be combined to bioinformatics modeling to unravel the role of redox-based PTMs associated with the responses to diverse physiological conditions or with different genetic backgrounds in two model unicellular eukaryotes: the yeast S. cerevisiae and the green alga C. reinhardtii. By providing a method to understand the dynamics of redox-based PTMs, this project is expected to profoundly modify our knowledge of cell signaling mechanisms and thereby have a high impact both for fundamental and biomedical research."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences microbiology phycology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences public health epidemiology modeling of diseases spread
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.