Objective
"Currently, the control of infectious diseases caused by pathogenic organelles displayed on bacteria is challenging for alternatives to antibiotic treatments. In this regard, the OMS report of 2010 alerted of the raising of antibiotic resistance for the control of human infections. Many of these pathogenic organelles, also known as pili or fimbriae, are assembled by a specific secretory machinery called the chaperone-usher pathway (CU). The aim of this proposal is the study of the initial steps required for the fimbriae assembly by the CU pathway (objectibe 1 and objective 3) and the identification of sequences involved in these steps (objective 2), using the E.coli Type 1 fimbriae prototype as the research model. The ultimate goal of INFIMAS project is the design of inhibitory peptides repertoires based on results obtained by the achievement of previous objectives, that will potentially overcome the bacterial resistance to the current antibiotics used for the treatment infectious diseases in EU and other countries.
In addition, the results derived from INFIMAS project will have an additional impact on the general scientific knowledge of the European scientific community, in particular, on the study of pathogenic bacteria organelles. With regard to the fellow, the Marie Curie Fellowship will offer her the opportunity to achieve high impact publications, to be trained in complementary skills and obtain the international research experience required to reach a maturity position after the completion of the proposal, as INFIMAS project will be developed in a high reputed institution, such as The Swiss Federal Institute of Technology, and be supervised and advice by Prof Glockshuber, a well known expert in the field of pathogenic organelles using Type 1 fimbriae of E.coli as the research model."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.