Identification and characterization of factors involved in chromosome organization and septum positioning in bacteria

Projektinformationen

COSP

ID Finanzhilfevereinbarung: 301995

Abgelaufene Finanzhilfevereinbarung

Startdatum 1 Februar 2013

Enddatum 31 Januar 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 200 371,80

EU-Beitrag € 200 371,80

Koordiniert durch

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom

Ziel

"The cell cycle is one of the most pivotal and fundamental processes in biology and encompasses a set of inter-related events, most prominently, chromosome replication, chromosome segregation and cell division. Each of these steps is highly complex, and bacterial cells offer the opportunity to study cell cycle processes in a simplified, relatively tractable context. Investigation of the bacterial cell cycle would not only be of benefit to basic understanding of this process in living organisms in general, it is also highly relevant to pathogenesis and antibacterial drug development.
Bacillus subtilis is a particularly good model for studying the bacterial cell cycle for several reasons. First, it is highly tractable as an experimental system. Second, the asymmetric cell division used during the early stages of sporulation, provides certain important experimental opportunities. Third, research on the cell cycle of B. subtilis is at the frontiers of our knowledge about this process.
By setting up genetic screens based on asymmetric cell division during sporulation in B. subtilis, this project aims to discover novel factors involved in proper chromosome organization and septum positioning, two important elements of the cell cycle. In addition, chromosome condensation will be studied in more detail using methods based on chromosome conformation capture (3C) technology. By exploiting the wide array of molecular and cell biology tools and techniques available in the host lab, the function of the identified factors will be further investigated.
Overall, this project is expected to yield novel insights into the bacterial cell cycle, especially with regard to chromosome structure and placement of the septum during cell division. Also, the project and research environment offer the researcher an excellent opportunity to develop scientifically and prepare for a leading independent position."

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › cell biology
• natural sciences › biological sciences › genetics › chromosomes

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2011-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

UNIVERSITY OF NEWCASTLE UPON TYNE

Kontakt Verwaltung

Fiona Airey (Ms.)

• EU-Beitrag: € 200 371,80
• Adresse: KINGS GATE ; NE1 7RU Newcastle Upon Tyne ; Vereinigtes Königreich
• Region: North East (England) › Northumberland and Tyne and Wear › Tyneside
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten