Objective
Normal aging is associated with declines in episodic memory and executive functions. Research suggests that around 20-50% of clinically healthy individuals show significant accumulation of amyloid, one of the hallmark biomarkers of Alzheimer’s disease but it has been difficult to establish the functional impact of amyloid burden in healthy older adults. Decreases in dopaminergic functioning in old age have been shown to mediate age-related changes in various cognitive domains. This project uses state-of-the-art positron emission tomography, functional magnetic resonance imaging and sensitive neuropsychological testing to disentangle the functional impact of amyloid pathology from those of dopaminergic effects on cognition in clinically healthy older individuals. It is hypothesized that dopamine and amyloid burden will have dissociable effects on cognition and brain network connectivity. The results of the proposed project will have important implications for characterizing the early preclinical phase of Alzheimer’s disease and aid the development of strategies for early identification of incipient neuropathological processes. The research will take place during the 24-months outgoing phase at Harvard University and Massachusetts General Hospital in Boston, MA, USA, and be followed by a 12-months reintegration phase at the Umeå Center for Functional Brain Imaging in Sweden. This IOF will lead to new insights into the neurobiological processes of cognitive aging and early Alzheimer’s disease, contribute to the accumulation of scientific skills and excellence in Europe, and enhance the career opportunities of a young female researcher in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine pathology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
901 87 UMEA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.