Objective
Advances in biotechnology propose innovative tools particularly relevant for public health application by genetic manipulation of microbial symbionts of arthropod vectoring disease. The symbiont engineering prevents the transmission of pathogens to human by interfering with their stage within the arthropod, thorough the expression of anti-pathogen effector molecules. This approach, defined paratransgenesis is simpler than the proposed engineering of the vector itself (transgenesis) and implies minor applicative and ethical concerns. Identification of good candidate for paratransgenesis has opened the way towards the investigation of microbes residing in the arthropod body, particularly those localised within the gut that often represents the locale in which pathogens transit or develop. Good paratransgenic candidates were already identified in the bug vectoring Chagas disease in South America and in the tse-tse fly vectoring sleeping sickness in Africa. As regard mosquitoes, responsible of tens of human infections including malaria, some interesting bacteria have been recognized as candidates for genetic manipulation, even if the ability of recombinant strains to cure mosquito has not been demonstrated yet in the field. Bacteria can be easily isolated, modified and reintroduced in the mosquito but secretion of antagonists by prokaryotic cell can represent a matter difficult to resolve. In this context endosymbiotic yeasts seem to be very appealing. Their genetic and cellular complexity makes yeasts as ideal tools for manipulation and bypasses many difficulties relative to the recombinant products releasing. On these bases, I have recently begun a study on the yeast microflora in mosquito. Particularly, I investigated the relationship between the yeast endosymbiont Pichia anomala and malaria vectors. Considering the special features of this yeast, I propose its use as paratransgenic tool for malaria control.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine psychiatry sleep disorders
- medical and health sciences health sciences infectious diseases malaria
- medical and health sciences health sciences public health
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-StG_20101109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
62032 Camerino
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.