Objective
Food safety and quality is one of the major priority in the European Society. The food manufacturing may change the biological properties of food compounds. One of the most common interaction between proteins and sugars occurs during food processing is Maillard reaction. The products of this reaction named advanced glycation end products (AGEs) may influence on human health by the interaction with receptor for advanced glycation end products (RAGE). In that way dietary derived AGEs may modulate the inflammatory pathways and play the role in the pathogenesis of variety diseases as allergy, cancer, cardiovascular diseases and diabetes. The aim of the research project is to establish the relationships between the processing technologies and pro-inflammatory properties of food. The influence of AGEs derived from soy processed flour on the pathogenesis of inflammation mediated via RAGE will be studied. The research project will connect the food technology and chemistry with molecular immunology. First part of research will focus on soy flour processing methods and technologies. Second and mean part of studies will focus on innovative, multilevel molecular studies of soy flour extracts. The experimental model will include the study of immunonmodulation on the intestinal level and immune level including: innate immune cells, allergy mediated cells and whole immune mononuclear cells presented in PBMC-model. The influence of soy extracts on expression of RAGE receptor and pro-inflammatory factors (NF-B, 100/calgranulin) and cytokine secretion will be determined. This complexity studies will provide the original information about pro-inflammatory potential of dietary compounds and may contribute to devise novel technological strategies to minimize formation of harmful compounds. Moreover, the achievements of multidisciplinary research on that field may contribute to improve the quality of life and reduction of economic costs caused by food-related diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine allergology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6708 PB Wageningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.