Objective
Mutations in GATA3, a dual zinc-finger transcription factor, cause the autosomal dominant hypoparathyroidism, deafness, renal dysplasia (HDR) syndrome, and down-regulation of GATA3 results in clear cell renal cell carcinoma. The renal abnormalities in HDR patients consist of cysts, renal aplasia/hypoplasia, mesangioproliferative glomerulonephritis, and vesicoureteral reflux. In the developing kidney, GATA3 is expressed in the ureteric bud along the branching process that gives rise to the collecting system of the definitive kidney, as well as in the glomerular mesangium and adjacent endocapillary cells. Nephric duct-specific inactivation of Gata3 leads to ectopic ureter budding as a result of premature nephric duct cell differentiation and loss of Ret receptor expression, leading to urogenital malformations such as kidney dysplasia, duplex systems, as well as vas deferens hyperplasia and uterine agenesis. While GATA3 has been identified to have a role in the developing kidney, little is known about its role in the adult kidney and the cellular pathways it regulates. Moreover, GATA3 has been shown to have a protective role in glomerulonephritis, however the molecular mechanisms of this process are unknown. Thus, the overall aim of this project is to define the role of GATA3 in normal adult kidney and in kidney models of glomerular disease. The specific aims are to: 1) assess the expression pattern of GATA3 in normal adult kidneys and in kidneys with glomerulonephritis; 2) determine whether heterozygous Gata3+/- mice are more susceptible to an earlier/more severe form of glomerulonephritis compared with wild-type mice; 3) investigate the role of GATA3 in the Wnt/beta-catenin pathway; and 4) identify the target genes of GATA3 in normal adult kidneys using ChIP-Seq. An integration of these data will advance our understanding of the cellular pathways regulated by GATA3 in the kidney and the molecular mechanisms giving rise to glomerular disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1090 WIEN
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.