Objective
Mitochondrial DNA (mtDNA) deletions accumulate in aged post-mitotic tissue and in individuals with neurodegenerative diseases, leading to local energy defects. Understanding the mechanism of mtDNA deletion formation is an essential step in trying to prevent their occurrence.
My hypothesis is that mtDNA deletions occur during mtDNA repair via a double strand break (DSB) repair pathway. I will address the different components of this hypothesis by mechanistic studies of cell lines derived from patients, transgenic cell culture and in vitro biochemistry.
This project also aims to identify and characterize novel mtDNA DSB repair factors. We will study candidate mtDSB genes by RNAi and confirm that the proteins are recruited to mtDNA after specific induction of mtDSBs. In a complementary approach we will search for protein interactions partners of the already identified mtDSB repair proteins by immunoprecipitations. Identified proteins will be analyzed in vitro, with the long-term goal to reveal the molecular details of human mtDSB repair.
Further we will use patient cell lines and transgenic cell culture to identify new therapeutic pathways that can be used to counteract mtDNA deletion formation in neurodegenerative disease and normal ageing. If we can show as I propose that repair is the mechanism underlying mtDNA deletion formation, increasing levels of antioxidants could prevent the induction of DSBs and mtDNA deletions in neurodegenerative disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
901 87 UMEA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.