Objective
"Globally some 200 million people live with Hepatitis C virus (HCV). HCV is one of the most problematic of the RNA viruses, with a slow indolent course of infection often characterised by decades of steady decline, with a significant fraction of infected subjects developing liver disease. Unfortunately our understanding of this disease has been hampered by a lack of virus culture systems and it is only now that we are beginning to develop the molecular tools to investigate the viral life cycle, an essential pre-requisite to developing any form of rational anti-viral therapy. We previously reported a crucial role for cAMP dependent protein kinase (PKA) in HCV infectivity. To carry out its function(s), PKA has to be delivered to its site of action within the cell, and this is achieved by scaffolding via A-kinase anchoring proteins (AKAP) which tether PKA to target membranes or organelles. Our recent data showing that: (i) HCV Core encodes a potential AKAP; (ii) recombinant HCV Core associates with PKA and (iii) HCV structural proteins negatively regulate cAMP-PKA responsiveness, support a novel mechanism for HCV to perturb PKA signalling. PKA plays an important role in the regulation of protein trafficking along the constitutive secretory pathways. By supplying an aberrant anchoring signal to PKA, HCV promotes its localisation to lipid droplets where virus assembly and egress of infectious particles occurs from the cell. This is the first report of a virus encoded AKAP that provides a novel mechanism for pathogens to hijack PKA signalling to defined cellular locations and to subvert host cell defence mechanisms. This proposal seeks to establish a new model of how HCV Core disrupts and re-targets cellular regulators and perturbs hepatocyte biology. Finally, the identification of peptides that specifically disrupt HCV AKAP-mediated protein-protein interactions will provide new targets for novel anti-viral drug design."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- medical and health sciences clinical medicine hepatology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.