Objective
"The proposed project (SAXCESS - Structure-function of Afamin by X-ray Crystallography Enabled Structure Solution) builds on preliminary results of a collaborative effort between the applicant (B. Rupp), an experienced structural biologist and crystallographer, based in California, with the group of Dr. Dieplinger, Associate Professor at the host institution (Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University Innsbruck). The SAXCESS project centers around the determination and analysis of the detailed molecular structure the human glycoprotein afamin, a vitamin E transporting protein, whose elevated levels are associated with all major parameters for the metabolic syndrome such as high blood glucose, hyperlipemia, obesity and high blood pressure. The immediate objective of this high-risk, high-reward project is the elucidation of the structure-function relationships of afamin following a flexible approach including parallel strategies and fall-back options. In the long term, the transfer of knowledge enabling the successful structure determination of afamin will open an entirely new direction of research at the European host laboratory and build the basis for a long-term collaboration between applicant and host on potential therapeutic applications. Detailed knowledge of the afamin structure will ultimately reveal the origin of its functional diversity and allow critical evaluation of its potential as a therapeutic target within already known but also yet unknown pathophysiological areas.
In addition to an excellent scientific record, the applicant has substantial experience as an educator, workshop organizer, and text book author. Special emphasis is placed on public awareness raising outreach activities and transfer of knowledge to the European host laboratory as well as overall enhancement of competitiveness and excellence in the European Research Area."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences educational sciences didactics
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- medical and health sciences basic medicine medical genetics
- medical and health sciences basic medicine pharmacology and pharmacy
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6020 INNSBRUCK
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.