Description du projet Challenging current ThinkingMagnetic Nano Actuators for Quantitative Analysis Afficher les objectifs du projet Masquer les objectifs du projet The MANAQA project is a multidisciplinary approach that combines innovative technologies emerging from different fields including nanotechnology, biochemistry, and nanorobotics. The strategy that will be exploited is based on a recently developed 5-DOF magnetic manipulation system combined with an atomic force microscope (AFM) system and functionalized magnetic nanowires. The fusion of these technologies has the potential to revolutionize many aspects of single-molecule manipulation and measurement. Information related to the structure and physical properties of macromolecules (i.e. proteins, polynucleotides) will be obtained. In a typical experiment, a molecule will be regiospecifically attached between a magnetic nanowire and the tip of an AFM cantilever. The extremely small footprint of the magnetic nanowire and the accuracy of a five degree-of-freedom magnetic manipulation system will allow high-resolution and stable force control on the molecule. The mechanical response of the molecule will be monitored using the AFM cantilever. Moreover, the system will be capable of measuring the electrical parameters of the nanowire-molecule hybrid. The success of this proposal will lead to long time-scale, low drift experiments that will provide invaluable insights on mechanisms governing conformational changes in single macromolecules by elucidating protein folding/unfolding/refolding trajectories at a low-force regime. This will contribute to the long-term vision of MANAQA of establishing a biomolecular measurement platform with extended capabilities. MANAQA opens new avenues in disciplines such as biochemistry, pharmacy, and biomedicine. The development of new miniaturized electronic devices within the scope of MANAQA project with single chemical entities integrated as their components will revolutionize the field of Information and Communication Technologies (ICT). Champ scientifique engineering and technologynanotechnologynatural sciencesphysical sciencesopticsmicroscopynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingmedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Thème(s) ICT-2011.9.1 - Challenging current Thinking Appel à propositions FP7-ICT-2011-C Voir d’autres projets de cet appel Régime de financement CP - Collaborative project (generic) Coordinateur EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Contribution de l’UE € 774 124,00 Adresse Raemistrasse 101 8092 Zuerich Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Contact administratif Salvador Pané Vidal (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire HIRTENBERGER ENGINEERED SURFACES GMBH Autriche Contribution de l’UE € 307 900,00 Adresse LEOBERSDORFER STRASSE 31-33 2552 HIRTENBERG Voir sur la carte Région Ostösterreich Niederösterreich Niederösterreich-Süd Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Wolfgang Hansal (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée AEON SCIENTIFIC AG Suisse Contribution de l’UE € 462 298,00 Adresse TANNENSTRASSE 3 8092 ZURICH Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Dominik Bell (Dr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Allemagne Contribution de l’UE € 214 161,00 Adresse SANDERRING 2 97070 Wuerzburg Voir sur la carte Région Bayern Unterfranken Würzburg, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Christian Gloggengiesser (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITAT AUTONOMA DE BARCELONA Espagne Contribution de l’UE € 449 633,00 Adresse EDIF A CAMPUS DE LA UAB BELLATERRA CERDANYOLA V 08193 Cerdanyola Del Valles Voir sur la carte Région Este Cataluña Barcelona Type d’activité Higher or Secondary Education Establishments Contact administratif Francisca Rabadán Sotos (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BOGAZICI UNIVERSITESI Turquie Contribution de l’UE € 567 186,00 Adresse BEBEK 34342 Istanbul Voir sur la carte Région İstanbul İstanbul İstanbul Type d’activité Higher or Secondary Education Establishments Contact administratif Hamdi Torun (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée