Objectif The ability of T cells to respond to a second encounter with antigen is an essential element of memory immunity and indeed a prerequisite of a successful vaccination. Many recent advances have been made in our understanding of the cellular basis of immunological memory (reviewed by Kaech) (1). However, major gaps in our knowledge on the generation and persistence of cell mediated immunological (CMI) memory still exist. In particular, factors that allow vaccines to generate long-lived memory are still not understood. It has been suggested that this may be one of the major drawbacks of non-replicating vaccines such as recombinant subunit vaccines (1).In this regard, mice cleared of an infection with tuberculosis (TB) respond vigorously upon re-exposure to mycobacteria and are efficiently protected against re-infection, whereas the efficacy of some subunit vaccines declines over time as shown in fig. 1. The reasons for this are unknown. This data clearly demonstrates the need of more fundamental studies of immunological memory induced by vaccines. Champ scientifique medical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.3 - Marie Curie Incoming International Fellowships (IIF) Appel à propositions FP6-2002-MOBILITY-7 Voir d’autres projets de cet appel Régime de financement IIF - Marie Curie actions-Incoming International Fellowships Coordinateur STATENS SERUM INSTITUT Contribution de l’UE Aucune donnée Adresse Artillerrivej 5 COPENHAGEN S Danemark Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
