Obiettivo The continuously rising prevalence and incidence rates of end stage renal disease (ESRD) in Europe represent a serious public health problem. Patients with ESRD exhibit a tremendously increased mortality due to cardiac disease (CD) compared to the age matched general population. Although the CD-protective effects of Angiotensin-Converting Enzyme Inhibitors (ACEI) and AT1 Receptor Blocker (ARB) are generally accepted in high-risk populations, only scarce data exist for patients with ESRD treated by renal transplantation. To extrapolate the effectiveness of ACEI/ARB on CD prevention to ESRD patients may not be appropriate, since it has recently been shown that some of the traditional CD risk factors such as arterial hypertension, hypercholesterolemia or body mass index are even negatively associated with CD events and mortality in ESRD patients. Similarly, the effectiveness of these drugs on transplant survival remains elusive. Therefore the applicant will elucidate the specific issue of whether the use of ACEI or ARB in ESRD is associated with patient and transplant survival.The Austrian/Eurotransplant databases will be utilized to answer the proposed issues, since the few large renal transplant databases UNOS, USRDS or CTS do not contain a complete follow up of important CD risk factors and medication. Sample size calculations revealed the feasibility of the proposed research. The actual analysis of the data will be performed at the Harvard School of Public Health under the supervision of Dr. G. Curhan, faculty in the epidemiology department. Starting in summer 2004, the applicant will receive three months of thorough training in clinical epidemiology at the HSPH and among completion starting with the analysis of the proposed project. After conclusion of the study in end 2005, the applicant will return to his home institution to conduct further studies and use the gained expertise to set up a training program in clinical effectiveness. Campo scientifico social sciencessociologydemographymortalitynatural sciencescomputer and information sciencesdatabasesmedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesclinical medicinenephrologymedical and health sciencesclinical medicinetransplantation Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Invito a presentare proposte FP6-2002-MOBILITY-6 Vedi altri progetti per questo bando Meccanismo di finanziamento OIF - Marie Curie actions-Outgoing International Fellowships Coordinatore MEDICAL UNIVERSITY OF VIENNA Contributo UE Nessun dato Indirizzo Waehringer Guertel 18-20 VIENNA Austria Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto HARVARD SCHOOL OF PUBLIC HEALTH, HARVARD MEDICAL SCHOOL, BRIGHAM & WOMEN'S HOSPITAL Stati Uniti Contributo UE Nessun dato Indirizzo 677 Huntington Ave BOSTON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
