Objective
Wild fish stocks are coming under strain as the demand for cheap sources of protein increases. As a result, aquaculture has expanded to an industrial scale and now accounts for over a third of total fisheries production. The exceptional conditions farming imposes on commercial fish species is driving the emergence of new and more virulent bacterial pathogens, with huge associated economic losses to the sector. Correspondingly, antiobiotic use in aquaculture is widespread. Antibiotic resistance in fish pathogens is also now common. Indiscriminate antibiotic use contaminates the consumer food chain, threatens human populations via the lateral transfer of resistance genotypes to human pathogens, and ultimately reduces the effectiveness of these drugs in a clinical and veterinary context. Thus, there is an urgent need to limit the use of antibiotics in aquaculture and to find alternative strategies to treat outbreaks of bacterial disease. In this proposal the opportunistic bacterial pathogen F. columnaris is the target of study. This organism causes fatal skin disease in a range of freshwater fish species including catfish and salmonids. At Laval University, Quebec a unique in vivo model of this disease is in place - the Brook Charr. Furthermore, at Laval an effective in vivo probiotic comprised of four endogenous skin bacteria has just been developed. We propose to use next generation pyrosequencing to profile the surface microbiome of this fish in health and disease. Furthermore, we propose to use in vitro competition assays between probiotics and pathogen, in combination with Illimuna sequencing, to study the metatranscriptomics of a model antagonistic ecological interaction. Drawing on expertise at the Universite de Laval, as well as that at the world class Marine Ecology and Fisheries Genetic Laboratory, UK, this proposal will establish the molecular basis for this probiotic effect to inform the development of similar approaches in other diseases and fish species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences biological sciences freshwater biology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences zoology ichthyology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LL57 2DG Bangor
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.