Objective
Cell death has a central role in innate immune responses in both animals and plants. The hypersensitive response (HR) is a plant-specific form of programmed cell death (PCD) occurring at the site of attempted pathogen invasion. A tight regulation of HR is essential in order to avoid unnecessary tissue damage beyond the infection site. However, the signaling pathways leading to HR still remain ill-defined. We have shown that Arabidopsis metacaspases antagonistically control pathogen-triggered HR. This project focuses on studying the precise molecular mechanisms underlying PCD control by this family of proteins. I have built a very broad platform of genetic and molecular tools that I can now use moving forward with research questions that will continue informing plant and animal biologists.
We will use a multidisciplinary approach, benefitting from transnational collaborations already established by the candidate with EU countries and the USA, which will ensure the continuity of the candidate’s high-impact research in the host institute, an emerging reference center for plant sciences. Our project aims at understanding the molecular mechanisms underlying pathogen-triggered HR cell death control by metacaspases in Arabidopsis and the role of metacaspases in developmental PCD. This knowledge will be translated into melon, by analyzing the role of melon metacaspases in HR cell death triggered by economically relevant pathogens in this horticultural model crop species. Findings derived this study could be extended to other pathosystems, to increase production in the field, and will help establishing the host institution as the reference center for melon research. A Marie Curie Career Integration Grant will allow reintegration of the candidate and establishment of a platform where the expertise of the candidate will complement and synergize with that of the host groups and receiving institution, contributing to European excellence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences botany
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
08193 Cerdanyola Del Valles
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.