Cel An effective malaria vaccine is needed, particularly against P. falciparum as this species causes more human mortality than all other eukaryotic pathogens combined. An understanding of natural selection operating on parasites in local endemic populations can enable understanding of core molecular mechanisms of global relevance. The objectives are to- Advance understanding of alternative pathways of erythrocyte invasion by malaria parasites- Advance understanding of immune evasion by malaria parasites- Identify optimal combinations of parasite proteins as malaria vaccine candidates- Develop the interface between population genomic and functional studies of malaria parasitesThe research programme will take an integrated approach to understanding pathogen adaptation, by designing experiments that are based on analysis at the molecular, functional, and population levels.(i) Population genetic analyses of P. falciparum in sites of contrasting endemicity in West Africa, to finely determine signatures of selection with high-resolution throughout the genome, and help refine hypotheses on mechanisms used by merozoites to invade erythrocytes and evade acquired immune responses.(ii) Experimental culture analysis of merozoite invasion into erythrocytes to identify the receptor-ligand interactions used by different parasite populations ex vivo. Novel receptor knockdown assays on cultured erythrocytes will be employed, and parasite adaptation experiments conducted to identify constraints on the use of alternative invasion pathways(iii) Innovative approaches to select individual parasites and characterise cell tropism, transcript profiles, and genome sequences. This is aimed to validate population level findings and revolutionise approaches to genetics and phenotyping of parasites in the future. Candidate molecule discoveries will be taken forwards to receptor-ligand interaction assays, antibody inhibition and immuno-epidemiological studies. Dziedzina nauki medical and health scienceshealth sciencesinfectious diseasesmalariasocial sciencessociologydemographymortalitymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-ID1 - ERC Advanced Grant Interdisciplinary Panel Zaproszenie do składania wniosków ERC-2011-ADG_20110310 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Wkład UE € 2 600 083,00 Adres KEPPEL STREET WC1E 7HT London Zjednoczone Królestwo Zobacz na mapie Region London Inner London — West Camden and City of London Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Stephen Ford Cima Dip Ma (Mr.) Kierownik naukowy David Joseph Conway (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Zjednoczone Królestwo Wkład UE € 2 600 083,00 Adres KEPPEL STREET WC1E 7HT London Zobacz na mapie Region London Inner London — West Camden and City of London Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Stephen Ford Cima Dip Ma (Mr.) Kierownik naukowy David Joseph Conway (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITE DES SCIENCES DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO Mali Wkład UE € 87 000,00 Adres QUARTIER ACI 2000 RUE 405 PORTE 359 BP1805 Bamako Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Salif Camara (Mr.) Linki Kontakt z organizacją Opens in new window Koszt całkowity Brak danych MEDICAL RESEARCH COUNCIL Zjednoczone Królestwo Wkład UE € 87 000,00 Adres 20 Park Crescent W1B 1AL LONDON Zobacz na mapie Rodzaj działalności Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Kontakt administracyjny Dembo Kanteh (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITE CHEIKH ANTA DIOP DE DAKAR Senegal Wkład UE € 87 000,00 Adres Avenue Martin Luther King - Dakar Fann Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Ndeye Astou Fall Cisse (Ms.) Linki Kontakt z organizacją Opens in new window Koszt całkowity Brak danych UNIVERSITY OF GHANA Ghana Wkład UE € 87 000,00 Adres LEGON BOUNDARY ROAD N/A LEGON ACCRA Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Nana Oye Akuffo (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
