Objective
Prenylation is a postranslational process leading to changes in protein structure due to the incorporation of a lipidic moiety that significantly modifies their physicochemical properties and their behaviour. Prenylation is therefore a crucial step for key cell processes, such as interaction between proteins, cell and differentiation, cytoskeletal function and vesicular trafficking. The modification of prenylation is proposed as an attractive option in biological and therapeutic research, as its alteration can cause significant changes in cell biology. In fact, several prenylation inhibitors are currently included in preclinical and clinical research as anticancer agents (Sasaki M, 2003; Mach F, 2002). Many prenylation-modified processes can be considered of immune or inflammatory nature. In addition, a major substrate for prenylation reactions are small G proteins, which are involved in the activation of some relevant signaling pathways in the immune system. Thus, the immune response could be controlled by modulating prenylation.
Specific cell-type inhibition of prenylation could be interesting allowing a better knowledge of its implication in cell biology considering several cell types related to the immune response. A novel technique for in vivo experiment is the genetic design of animals suffering from a cell-specific deficiency in the expression of a particular protein. This project is intended to study the influence of the lack of expression of one of the major enzymes involved in prenylation, GGTaseI, specifically in several cell types related to immune response, such as intestinal epithelial cells or lymphocytes. We will create strains by crossing Pggt1b-flox mice (Sjogren AK, 2007) with Villino-Cre mice (deletion of GGTaseI in epithelial cells) or with CD4-Cre mice (deletion of GGTaseI in CD4 + T cells) and do analysis of the evolution of these mice after several models of inflammation-associated colon cancer (AOM / DSS model) or in colitis models.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology colorectal cancer
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91054 Erlangen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.