Objective
The proper trafficking of membranes and associated proteins in neurons is crucial for the function of the nervous system. Myosin-VI is an actin-based cytoskeletal motor that promotes membrane trafficking and is suggested to play crucial roles in neurons. Most notably, the myosin affects the intracellular trafficking of AMPA receptors, major neurotransmitter receptors composed of transmembrane protein subunits. In addition, data suggest a potential link between myosin-VI and neurodegenerative diseases such as Alzheimer’s. Here, we want to dissect the molecular mechanism by which myosin-VI acts in AMPA receptor trafficking in neurons. Furthermore, we aim to determine the relevance of myosin-VI-driven AMPA receptor trafficking events for structure, function and plasticity of a well-characterized neuronal circuit, and for behavioral output. To this end, we will focus on Purkinje neurons as a model system. These cerebellar neurons are crucial for the coordination and fine-tuning of movements and for certain forms of motor learning. We will make use of genetically altered mice in combination with approaches such as transfection and live cell microscopy of cultured Purkinje neurons, in vitro genetic rescue experiments, ultra-structural analyses via electron microscopy, electrophysiological methods and behavioral tests. We expect that our study will provide novel, general insights into the mechanism by which myosin-VI functions in membrane trafficking. In particular, the results should shed new light onto the molecular and cellular events that take place in Purkinje neurons and determine output from the cerebellum. Moreover, understanding the mechanism of function of neuronal myosin-VI might impact our view of the pathogenesis of neurodegenerative disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
20251 Hamburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.