Objective
Proprioception involves the sense of limb position and movement of body parts. It is critical for motor control, as without knowing where your body parts are it is impossible to move them accurately. Proprioception relies on the integration of various inputs, from muscle spindle receptors, Golgi tendon organs, skin stretch receptors, visual, auditory and vestibular inputs, and signals of motor command. How and where these signals are integrated in the human brain is still unclear.
Here we will use state-of-the-art brain imaging and brain stimulation methods in combination with perceptual illusions to identify neuronal populations that are involved in the integration of multisensory and efferent motor command signals for proprioception. Our hypothesis is that the primary motor cortex is involved in this process by storing a common neuronal representation of motor commands and movement sensations. Furthermore, the posterior parietal cortex is hypothesised to play an essential role in the integration of multisensory signals to optimise the sense of limb position.
To test these predictions we will use limb-movement illusions induced by different combinations of efferent or afferent signals. In the efferent-induced illusory condition, subjects perceive movement when they try to move a limb, while this movement is prevented by either an ischemic or a physical block. In the afferent-induced condition, subjects perceive movement when their muscle stretch receptors are stimulated with tendon vibration. The role of visual signals will be studied by providing visual feedback of moving limbs with virtual reality technology. To identify groups of neurons with specific properties, we will use fMRI-adaption methods that extend the spatial limitation of traditional fMRI. After having identified key areas associated with proprioception, we will examine the causal interactions between them using neuronavigation-guided single-pulse and repetitive transcranial magnetic stimulation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.