Objective
"Chirality is fundamental to the vast majority of molecular recognition processes. Therefore, asymmetric synthesis is a cornerstone in the efficient production of modern pharmaceuticals and many other chemicals. Despite ongoing efforts, however, the asymmetric halogenation of olefins using intermolecular nucleophiles has not been achieved with useful enantiomeric excess ratios. The development of a feasible approach has challenged the field to the day. It is highly desirable for the tremendous expansion of scope it would offer regarding both olefins and nucleophiles applicable. This new reaction type also bears huge potential of generating complexity from relatively simple achiral starting materials, eliminating the need for complicated synthesis of the latter.
In this IEF project, a new method for the asymmetric halogenation of olefins involving intermolecular attack of the nucleophile will be developed. The ligand-based tuning of the stability of the halonium complexes of the olefins will allow for chiral induction even during the attack of an intermolecular nucleophile.
To achieve this goal, the fellow will combine his knowledge on synthesis and modern solution NMR techniques with the excellent infrastructure provided by the host institute. He will profit by strengthening his background in the elucidation of molecular interactions by NMR and from the large number of additional competencies he will acquire during his work, especially in the area of advanced (chiral) HPLC, UV spectroscopic kinetic studies and the expertise on asymmetric synthesis he will gain.
He will be able to raise his profile by high-impact publications on this hot topic that still leaves room for genuinely new findings. His chances of reaching an independent position in science will benefit greatly from his strengthened CV as well as from the extended network of scientific contacts he will be able to make at the very international host and upon visiting scientific conferences."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
405 30 Goeteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.