Objective
Genes tend to aggregate, nucleotide usage tends to change over large domains and yet, reasons for this are poorly understood. This suggests that there exists unknown molecular processes at work for millions of years and that shape the structure of modern genomes. Understanding the organization of genomes is another way to look into these molecular processes. Particularly relevant are DNA repair and chromatin processes, which can have a significant impact on the global organization of a genome. In this project, we hammer out the concept of chromatin print; which represents the effect of the local chromatin structure on the evolution of genomes through DNA repair. The existence of the chromatin print is no longer to be established, but the nature and strength of the phenomenon escape experimentation for lack of appropriate technologies. We are developing a method called TRIP for Thousands of Reporters In Parallel to precisely tackle this issue. The goal of this project is to develop and use TRIP to obtain a genome-wide dataset revealing how double-strand breaks occur and are repaired in different chromatin environments. This will give a clearer picture of the evolution of regulatory sequences and of the strength of the chromatin print. In the long term, knowledge of mutation-prone sequences might be used for routine prenatal checks of human syndromes caused by de novo mutations such as autism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
08003 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.