Objective
Background: Cardiovascular diseases (CVD), e.g. Myocardial Infarction (MI) and stroke, are the leading cause of death, accounting each year for more than 17.5 million people worldwide, 25% of which is in Europe. Cardiac bioengineering is a new research area to develop grafts and patches to replace or repair damaged heart tissue. However, a fully functional graft has not yet conceived. The main goal of this project is to develop bioengineered heart patches to induce regeneration of the tissue and restore heart functions after MI.
Aims: the aims and the results hoped for are:
1. To develop collagen-based nano-fibrous scaffolds that are:
a. Biocompatible and biodegradable, e.g. favour cell growth, and allow regeneration of the
host tissue and remodel with the growing heart.
b. Robust, elastic, and contractile that matches heart muscle.
c. Conductive to electrical impulses generated by the heart.
d. Porous enough to enable exchange of nutrients and waste from the patch.
e. Non-thrombogenic to ensure the patch will not cause thrombosis.
2. To significantly reinforce the biomedical research in Europe through efficient use of the allocated budget toward my integration into a more permanent position in Sweden, as well as enhancing knowledge transfer and cooperation between EU and Canada.
Research Strategy: I have previously developed hybrid interpenetrating polymer networks (HIPN) as bioengineered corneas that were mimetic of the natural cornea and successfully implanted into corneas of pigs with seamless host-graft integration and regeneration of the host cornea. HIPN is a core concept that can be tailored for various tissue applications. I therefore propose to engineer HIPN scaffolds for cardiac patches mainly comprised of collagen, and carbon nanotubes. I joined Linkoping University in March 2011 as an Assistant Professor from Canada. My expertise in tissue engineering combined with expertise of the host in Nanobiotechnology is an excellent match for this project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
581 83 Linköping
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.