Objective
"The aim of the ILLUMINATING NERVES project is to develop and synthesize new imaging agents that eventually can be used for surgical guidance around delicate nerve structures. The applicants research group already has made a major contribution to the clinical field of surgical guidance by introducing a concept wherein a multimodal/hybrid, imaging agent is used to provide fully integrated preoperative 3D imaging, surgical procedure planning, and real-time surgical fluorescence guidance. Illumination of delicate anatomical structures like nerves will have a direct influence on the quality of life of patients and as such creates a new window of opportunities for surgical guidance and for the chemical development of hybrid imaging agents. To illuminate both somatic and autonomic peripheral nerves, imaging agents will be developed that bind to receptors on myelinating Schwann cells and/or accumulate in neurons. These different targeting concepts dictate the use of different scaffold molecules varying from targeted antibodies to modified neurotoxin proteins that act as bionanoparticles and viral capsids, each scaffold demanding different synthetic routes for functionalization. For this particular application, the visualization of small nerves, especially the fluorescent imaging contrast has to increase compared to conventional imaging agents. The applicant’s multidisciplinary track record the chemical and (bio)medical field, combined with his proven ability to bridge the gap between bench and bedside aids in the successful integration of synthetic chemical strategies with biomedical assays and in vitro/in vivo validation studies. Although possibly providing interesting imaging agent candidates suitable for optimization towards a future clinical translation, the project will mainly generate fundamental insight in the types of (hybrid) imaging agents that have potential for the surgical illumination of peripheral nerves."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences clinical medicine surgery surgical procedures
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111012
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
2333 ZA Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.