Objective
Viruses are of great importance for global public health. The first line of cellular defenses against viral infection begins with the binding of viral RNA to intracellular pathogen recognition receptors. Such interaction triggers the conformational change of these receptors and allows subsequent interaction with the adaptor molecule MAVS. Once activated, MAVS recruits a signaling complex able to activate transcription factors that induce the direct expression of ‘early IFN stimulated genes’ (ISGs), which have direct anti-viral effect.
Until recently, the key adaptor molecule MAVS, was thought to localize exclusively at the mitochondrial membrane, therefore establishing mitochondria as a unique platform for antiviral signaling. Recent work has revealed that MAVS is also found on peroxisomes, organelles that are best known for lipids oxidation. Interestingly, peroxisomal MAVS induces a direct, rapid and transient, IFN-independent expression of ISGs, whereas mitochondrial MAVS induces both IFN and ISGs with delayed kinetics. Therefore, MAVS localization determines the type of signaling pathway activated during viral infection. The set of genes that are induced by peroxisomal MAVS and mitochondrial MAVS differ, suggesting that signaling from both organelles may be coordinated to ensure maximal antiviral gene expression.
We propose to characterize the molecular basis for the regulation and coordination between peroxisomal and mitochondrial MAVS signaling in the context of infection by a variety of medically important viruses. The overall goal of this project is to understand innate immunity mechanisms that are taking places very early after virus infection. A better understanding of this arm of the innate immune response should shed some light on important mechanisms such as the control of virus replication by the host cell, the cell tropism of the virus and the development of disease. Such understanding is key to the development of strategies to fight viruses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences public health
- natural sciences biological sciences microbiology virology
- natural sciences chemical sciences electrochemistry electrolysis
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.