Objective
"Protein prenylation is essential for the viability of all eukaryotic cells. Prenylated proteins regulate fundamental processes such as cell growth, differentiation and movement. Therefore, it is not surprising that prenylated proteins play a critical role in the pathophysiology of human diseases such as cancer and atherosclerosis. Indeed, mutations in the farnesylated oncogene Ras are found in 10-15% of all human tumors. Recent studies demonstrated that PDE6D acts as a soluble chaperon of Ras, thus it might regulate its oncogenic activity. In addition, PDE6D is important for the efficient transport of the rhodopsin kinase GRK1 and the alpha and beta subunits of PDE6 from the ER to the outer segments of cones and rods cells. Thus may play a critical role in normal vision physiology. PDE6D is conserved and has homologs across the animal kingdom. In the C. elegans worm, RNAi experiments against the PDE6D homolog pdl-1 failed to produce any abnormalities in the nematode physiology or behavior. However, we isolated a pdl-1 suppressor mutant that inhibits the fast recovery of worms after hypoxic stress.
We demonstrated that pdl-1 regulate the correct localization of the O2 sensor gcy-35. Thus, pdl-1 is essential for normal O2 responses in the C. elegans worm. Based on those finding my research proposal aims to:
1) Understand how pdl-1 is transported inside cells and elucidate novel regulators of its activity.
2) Identify new PDL-1 substrates, and explore their function in the C. elegans brain.
Hence, my research proposal aim is to understand protein prenylation regulation at all levels; from the molecular signaling network to the physiology and behavior of the whole animal. For this aim, we use behavioral paradigms together with state of the art microscopy, biochemistry and computational methods. We hope that our studies will strengthen the prenylated protein field in Europe and assist in development of better therapies for cancer, and atherosclerosis diseases."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences computer and information sciences computational science
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.