Objetivo Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that currently affects 2% of the population in industrialized countries; the risk of LOAD increases in individuals beyond the age of 70 and it is predicted that the incidence of LOAD will increase 4-fold within the next 50 years which may cause a great socioeconomic problem. Early diagnosis and evidence-based interventions that improve the condition of LOAD patients are not available. Numerous studies revealed that LOAD is an age-related multifactorial disease, which is evident on the protein level in hardly accessible cerebrospinal fluid by decreased beta amyloid and increased hyperphosphorylated tau protein.The Medical University of Vienna and the diagnostics company Randox have already characterised LOAD related proteins in blood platelets that reflect features of neurons. These proteins indicate multifactorial interactions in LOAD leading to our holistic approach. The present project, unlike others, will simultaneously determine (epi)genetic, protein-specific, and metabolic parameters of LOAD patients.On the genetic level LOAD is associated with Apolipoprotein E4 polymorphism. Decreased vitamin B12 and folate and increased homocysteine levels are metabolic dysfunctions that may be linked to epigenetic changes in methylation patterns of LOAD relevant genes.The University of Vienna will identify metabolic LOAD markers in blood. The MUW will perform complementary (epi)genetic and proteomic studies, and will generate algorithms for multi-arrays. Significant (epi)genetic aberrations in LOAD will be translated into assays of a DNA Chip at Randox. In addition, the SME Ledo and the Polish University Politechnika Lodzka join their expertise to develop a standardised ready-to-use platelet isolation column for platelet purification.Only this intensive transfer of knowledge will achieve combined analysis of these different types of LOAD biomarkers which should allow accurate diagnosis and offer approaches to targeted therapy. Ámbito científico medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2011-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Convocatoria de propuestas FP7-PEOPLE-2011-IAPP Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinador MEDIZINISCHE UNIVERSITAET WIEN Aportación de la UE € 283 608,00 Dirección SPITALGASSE 23 1090 Wien Austria Ver en el mapa Región Ostösterreich Wien Wien Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Michael Freissmuth (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Randox Laboratories Ltd Reino Unido Aportación de la UE € 354 518,00 Dirección Diamond Road 55 BT29 4QY Crumlin Ver en el mapa Región Northern Ireland Northern Ireland Antrim and Newtownabbey Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo John Lamont (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos OLBRZYMEK LESZEK TADEUSZ LEDO P.P.H.U. LESZEK OLBRZYMEK Polonia Aportación de la UE € 36 706,00 Dirección ULICA GLINIANA 19 91336 LODZ Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Sylwia Olbrzymek (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos POLITECHNIKA LODZKA Polonia Aportación de la UE € 13 148,00 Dirección ULICA ZEROMSKIEGO 116 90 924 Lodz Ver en el mapa Región Makroregion centralny Łódzkie Miasto Łódź Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Bogdan Walkowiak (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITAT WIEN Austria Aportación de la UE € 59 320,00 Dirección UNIVERSITATSRING 1 1010 Wien Ver en el mapa Región Ostösterreich Wien Wien Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Juergen Koenig (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos