Objective
Computational modelling is changing the face of science. Many complex systems can be understood as embodied computational systems performing distributed computations on a massive scale. Biology is the discipline where these ideas find their most natural application: cells can be viewed as input/ output devices, with proteins and organelles behaving as finite state machines performing distributed computations inside the cell. This led to the influential framework of cell as computation, and the successful deployment of formal verification and analysis on models of biological systems.
This paradigm shift in our understanding of biology has been possible due to the increasingly quantitative experimental techniques being developed in experimental biology. Formal modelling techniques, however, do not have mechanisms to directly include the information obtained from experimental observations in a statistically consistent way. This difficulty in relating the experimental and theoretical developments in biology is a central problem: without incorporating observations, it is extremely difficult to obtain reliable parametrisations of models. More importantly, it is impossible to assess the confidence of model predictions. This means that the central scientific task of falsifying hypotheses cannot be performed in a statistically meaningful way, and that it is very difficult to employ model predictions to rationally plan novel experiments.
In this project we will build and develop machine learning tools for continuous time stochastic processes to obtain a principled treatment of the uncertainty at every step of the modelling pipeline. We will use and extend probabilistic programming languages to fully automate the inference tasks, and link to advanced modelling languages to allow formal analysis tools to be deployed in a data modelling framework. We will pursue twoapplications to fundamental problems in systems biology, guaranteeing impact on exciting scientific questions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences computer and information sciences computational science
- natural sciences computer and information sciences artificial intelligence machine learning
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111012
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
EH8 9YL Edinburgh
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.