Obiettivo Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothesis-driven reductionist approaches to understand the molecular basis of ageing. Whereas molecular and cellular damage is thought to be a cause of ageing and age-related pathologies, little is known about the molecular events that underlie ageing or determine longevity. A large number of progeroid syndromes that are characterized by an early onset of age-related pathology are linked to inborn defects in genome maintenance thus pointing towards damage in (nuclear) DNA as a major culprit of ageing and age-related pathology. DNA damage fuelled by intrinsic andenvironmental sources of genotoxic insult and by errors of genome maintenance mechanisms invariably accumulates with advancing age. The outcome of DNA damage is diverse and generally adverse: DNA lesions may physically obstruct essential processes including DNA replication and transcription. In addition, DNA damage activates checkpoint responses that lead to a reduction in cell proliferation potential (cellular senescence) or to an increase in cell death. As a result, depending on the type and severity of DNA injuries and the cellular response to DNA damage, these cellular mechanisms impair organ maintenance and function during ageing. The CodAge ITN proposes an integrated approach in studying the role of Chronic DNA damage in Ageing and age-related pathology. Campo scientifico natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsgenomes Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2012-ITN - Marie-Curie Action: "Initial Training Networks" Invito a presentare proposte FP7-PEOPLE-2012-ITN Vedi altri progetti per questo bando Meccanismo di finanziamento MC-ITN - Networks for Initial Training (ITN) Coordinatore UNIVERSITAT ZU KOLN Contributo UE € 792 370,78 Indirizzo ALBERTUS MAGNUS PLATZ 50931 Koln Germania Mostra sulla mappa Regione Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Heike Brucherseifer (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto IDRYMA TECHNOLOGIAS KAI EREVNAS Grecia Contributo UE € 910 022,52 Indirizzo N PLASTIRA STR 100 70013 Irakleio Mostra sulla mappa Regione Νησιά Αιγαίου Κρήτη Ηράκλειο Tipo di attività Research Organisations Contatto amministrativo Zinovia Papatheodorou (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF NEWCASTLE UPON TYNE Regno Unito Contributo UE € 570 113,28 Indirizzo KINGS GATE NE1 7RU Newcastle Upon Tyne Mostra sulla mappa Regione North East (England) Northumberland and Tyne and Wear Tyneside Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Aleona Blinova (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Italia Contributo UE € 240 837,96 Indirizzo VIA ADAMELLO 16 20139 Milano Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Research Organisations Contatto amministrativo Carlo Raimondi Cominesi (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato LEIBNIZ-INSTITUT FUR ALTERNSFORSCHUNG - FRITZ-LIPMANN-INSTITUT EV (FLI) LEIBNIZ INSTITUTE ON AGING - FRITZ LIPMANN INSTITUTE EV (FLI) Germania Contributo UE € 222 068,88 Indirizzo BEUTENBERGSTRASSE 11 07745 Jena Mostra sulla mappa Regione Thüringen Thüringen Jena, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Wilfried Briest (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Svizzera Contributo UE € 246 086,94 Indirizzo BATIMENT CE 3316 STATION 1 1015 Lausanne Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Joachim Lingner (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato MOSAIQUES DIAGNOSTICS GMBH Germania Contributo UE € 222 068,88 Indirizzo ROTENBURGER STRASSE 20 30659 Hannover Mostra sulla mappa Regione Niedersachsen Hannover Region Hannover Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Harald Mischak (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS Grecia Contributo UE € 222 068,88 Indirizzo ALEXANDER FLEMING STREET 34 16672 Vari Mostra sulla mappa Regione Αττική Aττική Ανατολική Αττική Contatto amministrativo Maria Denis (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ATLAS BIOLABS GMBH Germania Contributo UE € 222 068,88 Indirizzo KERPENER STRASSE 61-69 50937 KOLN Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Karsten Heidtke (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato