Objectif Plant defence depends on speed: the sooner a plant recognises its attacker, the more effective its defence response will be. Over the course of evolution, plants have acquired the ability to prime their immune system after perception of specific environmental signals. This heightened state of defence enables a faster and/or stronger activation of inducible defence mechanisms after pathogen attack, providing resistance against a wide range of diseases. Based on a phenotypically similar response in human immune cells, this plant resistance response is called “defence priming”.The primed defence state is not accompanied with an increased expression of costly defence mechanisms. Consequently, broad-spectrum disease resistance by defence priming is not associated with major reductions in plant growth and reproduction. Furthermore, defence priming can be maintained over a relatively long period of time, which is why it is often regarded as a form of immunological plant memory. Despite these attractive properties for application in sustainable agriculture, there are still many unanswered questions about the mechanistic basis of defence priming. The main objective of this ERC proposal is to elucidate the mechanisms underpinning two poorly understood aspects of the phenomenon:1. the onset of primed defence.2. the long-term maintenance of primed defence, including the intriguing phenomenon that the primed defence state can be transmitted from pathogen-exposed plants to their progeny.Using state-of-the-art techniques in the field of molecular biology, biochemistry, and (epi)genetics, this project will address the overarching question of how plants adapt their immune system to the conditions in their environment. This project will allow me to generate new insights in the regulation of plant defence and provide tools that can be used to develop novel strategies for sustainable crop protection. Champ scientifique natural sciencesbiological sciencesbiochemistrynatural sciencesbiological sciencesgeneticsagricultural sciencesagriculture, forestry, and fisheriesagriculturesustainable agriculturemedical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesmolecular biology Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS9 - ERC Starting Grant - Applied life sciences and biotechnology Appel à propositions ERC-2012-StG_20111109 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil THE UNIVERSITY OF SHEFFIELD Contribution de l’UE € 1 307 407,20 Adresse FIRTH COURT WESTERN BANK S10 2TN Sheffield Royaume-Uni Voir sur la carte Région Yorkshire and the Humber South Yorkshire Sheffield Type d’activité Higher or Secondary Education Establishments Contact administratif Claire Kennedy (Mrs.) Chercheur principal Jurriaan Ton (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire THE UNIVERSITY OF SHEFFIELD Royaume-Uni Contribution de l’UE € 1 307 407,20 Adresse FIRTH COURT WESTERN BANK S10 2TN Sheffield Voir sur la carte Région Yorkshire and the Humber South Yorkshire Sheffield Type d’activité Higher or Secondary Education Establishments Contact administratif Claire Kennedy (Mrs.) Chercheur principal Jurriaan Ton (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
