Objective
Chronic and neuropathic pain, usually diagnosed as spontaneous pain, hypersensitivity to pain or both, is a maladaptive response of the organism to injury and inflammation.
Finding new effective drugs to treat these debilitating conditions has shown particularly difficult, as compounds showing good efficacy in preclinical models often fail to meet clinical trials endpoints. A commonly accepted explanation for this discrepancy is that virtually all preclinical analgesic tests have only limited predictability, as they are based on models of evoked pain, whereas patients mainly seek relief of spontaneous pain.
To fill the gap in our knowledge of the mechanism of spontaneous pain and to accelerate the discovery process towards better analgesics, we propose to implement a new in vivo platform for deciphering pain pathways in animal models of spontaneous pain. A new electrophysiological approach, high throughput microneurography (HT-MNG) will be implemented by using in house nanotechnology and microelectronics. This approach will be combined with in vivo RNA interference and optogenetics and validated by specifically addressing targets known to be involved in chronic and neuropathic pain conditions.
The proposed preclinical in vivo platform has a great translational potential, as HT-MNG recordings from animal models will provide data directly comparable to those from human patients. Thus, we expect our project to significantly contribute in avoiding expensive failures in Phase II and Phase III pain studies due to lack of drug efficacy. Moreover, by opening the possibility to measure and recognize specific excitability patterns in peripheral neuropathies, the project can help identify patients more likely to respond to a particular drug, dose or regime, thus opening new opportunities for personalized medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics RNA
- engineering and technology medical engineering diagnostic imaging
- medical and health sciences basic medicine pharmacology and pharmacy
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
72770 Reutlingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.